Abstract: First-principle-study reveals stability or metastability of neon reactivity with ionic compounds at high pressure． The stability-driven factor is reduction of long-range Coulomb energy of the lattice． To verify this conclusion, neon was mixed with sodium oxide, sodium sulfide, or with potassium oxide and potassium sulfide, respectively, at high pressure． The resulting structures formed in a certain pressure range were found to be stable or metastable through numerical calculations and analysis． The source of stability of neon-containing compounds is summarized． This is of great significance in exploring the properties of neon at high pressures．