Abstract: Based on the newly added data of sports enterprises, a sports entrepreneurship activity index was constructed using the population method to evaluate the entrepreneurial vitality of sports enterprises in China during the 5-year interval from 2000 to 2020, and its development status was spatially processed. And explore the degree of agglomeration of regional sports entrepreneurship vitality and its driving factors through Moran index and geographic detector model. The research results indicate that: 1) At the national scale, the entrepreneurial activity of sports enterprises in China has increased from 0.323 in 2000 to 13.541 in 2020, showing a continuous upward trend. At the regional scale, the entrepreneurial activity of sports enterprises shows a spatial pattern of "high in the east and low in the west"; 2) The overall Moran index is greater than 0.2, indicating a positive spatial correlation between the activity of sports entrepreneurship in China. The local Moran index reflects the strong spatial clustering characteristics of sports entrepreneurship, and urban clusters play a strong radiating role in promoting sports entrepreneurship; 3) The purchasing power level is the core element that affects sports entrepreneurship, and innovation support, labor force level, marketization index, and national sports industry base construction all have a positive impact on sports entrepreneurship. Based on this, the following suggestions are proposed: 1) Pay attention to the spatial imbalance of sports entrepreneurship level and provide element support according to local conditions; 2) Utilize the entrepreneurial driving effect of urban agglomerations to achieve regional coordinated growth; 3) Make full use of the sports industry base and leverage its entrepreneurial carrier function.