Abstract: The “production-living-ecological” space has occupied a main position in human activities in terrestrial surface system, their reasonable planning and use helps promote development of harmony in human-land relations． Guangdong province is at the forefront of China’s reform and opening up, but it is also a potential area for “production-living-ecological space” conflicts． In this article spatial classification and identification of “production-living-ecological” space were done in Guangdong province, to study evolutionary characteristics from 2000 to 2020, to quantify spatiotemporal evolution of spatial conflicts, and to explore influencing factors on different scales． Of the “production-living-ecological” spaces in Guangdong province, the total area of ecological space remains the largest． However, in the past 20 years, evolution of the living space, production space, and ecological space became predominant successively． The overall degree of conflict among “production-living-ecological” spaces in Guangdong province is relatively low, with the characteristic of upper spatial clustering． Overall, NDVI, DEM, night light, slope, population, gross domestic product, and temperature have relatively strong explanatory power for conflicts of “production-living-ecological” spaces． On the local scale of between 4-30 km, effects of NDVI and slope on spatial heterogeneity of “production-living-ecological” spatial conflicts are significant． As the research scale increases, effects of population and temperature gradually increase．