Abstract: The concept and implication of meaningful learning is introduced, applications of meaningful learning in higher education teaching is summarized, for the course of "Remote Sensing Digital Image Processing"．The emphasis is to apply meaningful learning to teaching resources and implementation of SPOC (small private online course) flipped classroom．Information literacy is an important indicator to measure quality of higher education cultivation talents, and meaningful learning could improve learners' information literacy．Three points need to be noted in implementation．First, comprehensibility of curriculum resources should be highlighted．Second, inherent connection of knowledge should be emphasized．Third, stimulation of students’ intrinsic motivation should be stressed in teaching feedback．