CHIP蛋白在疾病中的作用研究进展

The role of CHIP in disease

摘要: CHIP (carboxyl terminus of Hsc70-interacting protein)又称STUB1 (STIP1 homology and U-box containing protein 1)，是一种分子伴侣结合蛋白，具有E3泛素连接酶活性．研究表明，CHIP蛋白在细胞体内通过蛋白质量控制系统调控细胞代谢、分化、增殖、迁移和肿瘤发生发展等多种生理病理过程．本文对CHIP在癌症及多种常见疾病中的作用进行综述，以期为临床治疗和药物开发提供潜在突破点．

Abstract: Carboxyl terminus of Hsc70-interacting protein (CHIP), also known as STIP1 homology and U-box containing protein 1 (STUB1), is a co-chaperone protein with E3 ubiquitin ligase activity． CHIP is known to regulate both physiological and pathological processes (cell metabolism, differentiation, proliferation, migration, and tumorigenesis) via protein quality control pathway． This review summarizes the role and molecular mechanism of CHIP in cancer and non-malignant diseases, with implications for clinical treatment and drug development．