预期眼动任务中反应时呈双峰分布的神经环路模型

A parallel neural circuit model for bimodal distribution of reaction time in a predictive saccade task

  • 摘要: 在执行精确时间内产生预期眼动的任务时,猕猴的反应时间呈现双峰分布.对这一现象,本文设计了包含大脑皮层的顶内沟外侧区(lateral intraparietal area ,LIP)和辅助眼区(supplementary eye fields,SEF)、基底节(basal ganglia,BG)与上丘脑(superior colliculus,SC)在内的并行神经环路模型,通过计算模拟复现出双峰分布.本文探究了该分布的神经机制,发现SEF和LIP神经元群体之间的竞争过程导致了2个峰的出现,并且SEF脑区主要负责预期性眼动,主导了第1个峰的出现,LIP脑区主要负责由视觉刺激引发的反应性眼动,主导了第2个峰的出现.本文进一步地讨论了影响双峰分布形态的关键参数,从计算神经科学的角度探索了时间预期执行的过程.

     

    Abstract: In predictive saccade tasks within precise time intervals, the reaction time of macaque exhibits a bimodal distribution. To investigate this phenomenon further, a parallel neural circuit model that includes the lateral intraparietal area (LIP), supplementary eye fields (SEF) in the cerebral cortex, the basal ganglia (BG) and superior colliculus (SC) is proposed in this study. Model simulations successfully reproduced a bimodal distribution. Competitive interaction among neuronal populations in SEF and LIP regions was found to give rise to two peaks. SEF region primarily was found to handle predictive saccades and dominated the first peak, while LIP region was found to be responsible for visually evoked reactive saccades and dominated the second peak. Key parameters that influence morphology of bimodal distribution are discussed. The process of time expectation from the perspective of computational neuroscience is explored.

     

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