Abstract: Neuroimaging studies of human brain connectomics have revealed abnormal functional connectivity patterns in individuals with autism spectrum disorder (ASD)． Previous works primarily focused on static functional connectivity, but diversity in functional connectivity patterns and their abnormal features in ASD remains to be elucidated． Statistical eigen-microstate analysis of resting-state functional magnetic resonance imaging data from 45 children (6-10 years old, all males) was performed in this study, which included 27 children with ASD and 18 healthy controls． It was found that certain (i.e., six in total) leading basic modes made a dominant contribution to whole-brain spontaneous activity for both healthy children and children with ASD． Each leading mode showed distinct spatial distribution of brain activity and corresponded to functional system-dependent connectivity pattern． Compared to healthy developing children, children with ASD showed altered functional connectivity patterns for the first, second, and fourth leading modes, primarily involving connectivity within the visual network and connectivity between the dorsal attention network and the frontoparietal, default-mode, and visual networks． These data suggest that multiple abnormal connectivity patterns simultaneously occur in functional brain networks of children with ASD, offering novel insights into mechanisms underlying brain network alterations in autism．