Abstract: Hydroxyapatite was prepared using biogenic phytic acid as phosphorus precursor and calcium hydroxide as calcium precursor．Hydroxyapatite was prepared by solid-liquid mixed ball milling combined with calcination．Optimum calcination temperature was 1 100 ℃, ball milling time was 2 h．Hydroxyapatite so prepared yielded high purity, and is a potential substitute for existing commercial supplies．